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49ers’ Brock Purdy returning to practice, ‘chance’ he plays in home opener against Cardinals

September 17, 2025
49ers’ Brock Purdy returning to practice, ‘chance’ he plays in home opener against Cardinals

SANTA CLARA – Brock Purdy is returning to practice today as the 49ers gauge his availability for Sunday’s home opener against the Arizona Cardinals.

“He does have a chance,” coach Kyle Shanahan said.

There is also a chance Purdy serves as the backup quarterback if the 49ers give Mac Jones a second straight start, Shanahan acknowledged.

A toe injury forced Purdy to sit out last week’s sessions and Sunday’s 26-21 win at New Orleans. Jones successfully filled in for Purdy, throwing three touchdown passes and no interceptions while fumbling once in his 49ers’ debut.

Purdy played through injuries to the big toe on his right foot and to his left (non-throwing) shoulder in the 49ers’ 17-13 season-opening win at Seattle. Purdy watched last Sunday’s win from the sideline, wearing sneakers rather than an orthopedic boot. Afterward, he was complimentary in an exclusive interview with this news organization when asked about Jones’ performance.

NOT PRACTICING

The 49ers will have several players out of practice:

Left tackle Trent Willliams (knee/rest)

Wide receiver Jauan Jennings (shoulder, ankle)

Running back Christian McCaffrey (calf, rest)

Defensive end Nick Bosa (rest)

Fullback Kyle Juszczyk (concussion)

Safety Siran Neal (concussion)

Defensive end Yetur Gross-Matos (knee)

Tackle Spencer Burford (knee)

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