How 49ers’ Kyle Shanahan has fared against the Arizona Cardinals

SANTA CLARA — In his ninth NFL season, 49ers coach Kyle Shanahan has had some of his toughest games in the NFC West against the Arizona Cardinals.

Going into Sunday’s game at Levi’s Stadium (1:25 PST, Fox), Shanahan’s teams are 7-9 against the Cardinals against four different coaches — Bruce Arians, Steve Wilks, Kliff Kingsbury and Jonathan Gannon.

The 49ers were swept last season, including a 24-23 loss at Levi’s Stadium in a game they led 23-10 entering the fourth quarter.

“When you change coaches it’s always different with scheme and stuff,” Shanahan said Wednesday. “And when you’ve got a quarterback like Kyler (Murray), regardless of who the game’s going or how good you’re doing you never know when he can do something off schedule.

“There’s not anything in particular, they’ve got good coaches and good players.”

A look at those 16 games:

Jan. 5, 2025

CARDINALS 47, 49ers 24: Arizona outscores the 49ers 19-0 in the fourth quarter. Josh Dobbs passes for 326 yards but is intercepted twice. Kyler Murray is 25-foir-35 for 242 yards, 4 TDs

Oct. 6, 2024

Cardinals 24, 49ERS 23: Shanahan was 38-0 with a 10-point lead in the fourth quarter. Murray opened the scoring with a 50-yard run but 49ers led 23-10 before letting it get away. Brock Purdy had two interceptions.

Dec. 17, 2023

49ers 45, CARDINALS 23: Christian McCaffrey carries 18 times for 115 yards and one touchdown and catches five passes for 72 yards and a third touchdown.

Oct. 1, 2023

49ERS 35, Cardinals 16: McCaffrey rushes 20 times for 106 yards and three touchdowns and catches seven passes for 71 yards and another score.

Jan. 8 ,2023

49ERS 38, Cardinals 13: Purdy is 15-for-20 for 178 yards and three touchdowns against Cardinals team quarterbacked by David Blough and Chase McSorley.

Nov. 21, 2022

49ers 38, Cardinals 10: At Azteca Stadium in Mexico City, Jimmy Garoppolo is 20-for-29 for 228 yards and four touchdowns.

Nov. 7, 2021

Cardinals 31, 49ERS 17: 49ers hit low point with a 3-5 record in a game the Cardinals led as much as 31-7 . The Cardinals rush for 163 yards, Colt McCoy is 22-for-6 and Garoppolo is sacked five times.

Oct. 10, 2021

CARDINALS 17, 49ers 10: With Garoppolo (calf) sidelined, Trey Lance is 15-for-29 and 192 yards and has 16 rushes for 89 yards in his starting debut.

Dec. 26, 2020

49ers 20, CARDINALS 12: Jeff Wilson leads a 227-yard rushing attack with 183 yards on 222 carries. Murray is 31-for-50 for 247yards and has eight rushes for 75 yards.

Sept. 13, 2020

Cardinals 24, 49ERS 20: Murray is 26-for-40 for 250 yards and rushes 13 times for 91 yards. DeAndre Hopkins catches 14 passes for 151 yards for Arizona.

Nov. 17, 2019

49ERS 36, Cardinals 26: Garoppolo completes 34 of 45 passes for a career high 424 yards, 4 touchdowns and 2 interceptions and rookie Deebo Samuel has eight receptions for 134 yards as 49er improve to 9-1

Jimmy Garoppolo (10) threw touchdown passes to four different receivers in a 28-21 win by the 49ers in Arizona on Oct. 31, 2019. AP Photo

Oct. 31, 2019

49ers 28, CARDINALS 25: Garoppolo is 28-for-37 for 317 yards and touchdown passes to George Kittle, Kendrick Bourne, Emmanuel Sanders and Dante Pettis.

Oct. 28, 2018

CARDINALS 18, 49ers 15: Josh Rosen hits Christian Kirk for the game winner with 34 seconds remaining and then the two-point conversion

Oct. 7, 2018

CARDINALS 28, 49ers 18: The 49ers outgain Arizona 447-220 but turn the ball over five times in falling to 1-4.

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Nov. 5, 2017

Cardinals 20, 49ERS 10: C. J. Beathard is 24-for-51 for 294 yards but is sacked five times for the 49ers. Adrian Peterson gains 159 yards on 37 carries as the 49ers fall to 0-9 in Shanahan’s first season.

Oct. 1, 2017

CARDINALS 18, 49ers 15, OT: a 19-yard pass from Carson Palmer to Larry Fitzgerald clinches it with 32 seconds left in overtime.

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