The 49ers couldn’t overcome their season-long injury issues Sunday as they fell in Tampa to the Buccaneers 30-19.

Fred Warner went down with a gruesome ankle injury in the first quarter, leaving the defense without its vocal leader in the middle.

The offense settled for a quartet of field goals from Eddy Piñeiro alongside Christian McCaffrey’s first rushing touchdown of the season. The Bucs had two rushing scores and Baker Mayfield passed for two more, going 17-of-23 for 256 yards.

Mac Jones, starting again for Brock Purdy, did not match Mayfield, the ultimate top pick-turned-backup-turned starter again, a course Jones is seeking to chart as the 49ers’ second-stringer. He completed 27 of 39 passes for 347 yards but had no touchdowns and two interceptions, being sacked six times and fumbling once.

Jauan Jennings returned to the lineup but only had one catch for seven yards, while Kendrick Bourne led the Niners with 142 yards on five receptions. McCaffrey topped 100 yards, with 54 on the ground and 57 receiving.

Here’s what the 49ers’ leaders said postgame:

Kyle Shanahan

On Warner’s injury:

Dislocated, I think it broke, too. So he’ll end up having surgery.

On the impact of losing Warner:

It’s big. Anytime you lose one of your best players, also a huge leader, it’s obviously a huge blow. I feel bad for Fred right now. He was in good spirits, though. He’s got a good foundation. I’ve got a lot of faith in Tatum (Bethune) and he’s the next man up. He’s going to have to do it throughout the year.

On his animated discussion with Jennings:

Just intense, competitive conversation between two people at the end of the second quarter, but we were all good.

On moving past an injury in-game:

It’s an NFL game. You got to move on. So I’m sure they’re crushed for him and everyone — not just the linebackers but everyone on our team feels for Fred. But that’s football. You saw how emotional everyone was when they saw him down, on both sides. But once that’s over, everyone’s got a job to do.

On injuries to the stars:

Everyone knows it’s difficult, when you lose your better players, your leaders. It’s huge with Nick, obviously huge with Fred. Hopefully we get Kittle back here and some of the other guys, But I mean, that’s going to give opportunities to other guys and these are moments guys got to step it up.

On Jauan Jennings:

Bad ankles, some issues with his ribs. Hasn’t had some full-speed practices. I was pumped that he was able to go today, but he’s struggling to go every week now.

On Kameron Johnson’s touchdown:

We had a bust on the motion. Someone dropped him and that’s why he was all alone.

On Tez Johnson’s touchdown:

Down the middle, single safety. Baker looked him off and threw a post. Shouldn’t be able to give up a post in single safety, and our middle-third guy got out of position. Baker made a hell of a play.

Mac Jones

On his oblique and knee injuries:

I feel good. … Nothing serious. Everyone’s dealing with stuff, and I just really want to get back out there at practice and see what I can do better.

On Warner’s injury:

He’s been the leader of this team for a long time, so really all you can do is just pray for him and know that we have his back. I was disappointed that I didn’t play better for him today.

On the early interception targeting Kendrick Bourne:

It’s a heavy pressure team so we have to just be more keyed in together. KB and I, we have a great connection and we just weren’t on the same page on that one.

On moving past the loss:

It’s early in the year. We’re not a bad football team. We just need to flip the switch and get ready for next week and get some guys back and be positive about it, honestly.

On Jennings playing through injury:

He didn’t have to play in this game and he chose to. He fought through some stuff, and he’s a fighter and that’s the DNA of our team — his personality. Really love him. He did a good job. We missed on a few things but it wasn’t our day and hopefully we have a lot of good days ahead.

On facing the Buccaneers defense:

I’ve gone against Todd Bowles a few times and whether it’s preseason or a really big game, he’s going to bring a different play on every play. So they did a good job. They had our number today.

Christian McCaffrey

On Warner’s injury:

It’s just heartbreaking. It’s such a weird game when you have to see somebody like that, what happened with Bosa earlier this year and then just have to continue to play. It’s kind of a weird deal but it’s heartbreaking. He’s one of the best players I’ve ever played with and one of the best leaders I’ve ever played with.

On his game:

We’ll have to look at that tape. I’m always my biggest critic, so we’ll see if it was a successful game or not. But I think there was probably some plays that I maybe want back.

On looking ahead to some offensive players returning from injury:

Just having more depth and having some guys come back with fresh energy, that’s a big deal.

JAUAN JENNINGS

On Warner’s postgame talk:

“Fred came and talked to us after the game. Lifted us up. Next-man mentality, trying to have his back. I was personally nauseous. I had to take some nauseous medicine. It just made me sick to my stomach. We’ve got to still drive the boat. Captain’s gonna lead the way and everybody else is going to step up.”

On Shanahan sideline spat:

“Oh man, you have to ask him. You had to ask him.

On his health

Playing with injuries is part of it. You’ve got high, low ankle sprains. You’ve got shoulder 20 percent. You’ve got five broken ribs. You keep playing. Nobody cares. You keep playing.

It’s football. I love pain. I wouldn’t be playing this sport if I didn’t.

On Warner:

He’s one of guys who led this team year in year out. His words of encouragement before every game. To know how much that guy loves the game, it’s very sad and it makes me sick to my stomach.

TRENT WILLIAMS

On offensive reinforcements

We have some really good players that we look to get back. That can only help, if we get more weapons in the fold.

On Warner’s exit

It’s heartbreaking. I mean, Fred is not only one of the best linebackers to ever play this game, he’s the heart and soul of this team, not just the heart and soul of this defense.

It’s one thing to see somebody go down and go to the blue tent and nobody really knows what’s going on. When you see a guy injured like that, it really is a gut punch and it’s truly really hard to continue the intensity and playing that game like that never happened.

You never get used to that. You see one of your really good friends and someone you have genuine love for, and you see him having to get carted off, it’s an emotional experience.

On postgame talk

Fred will never let you see him down. Even in the midst of what he’s going through, he wanted to address the team. He’s that type of guy. I’ll continue to play for him and hope he has a speedy recovery.

On penalty after interception in fourth quareter

Just talking trash. Frustrated. Just mixing it up.